Tenuta Livia M A, Cury Jaime A
Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
Monogr Oral Sci. 2013;23:108-24. doi: 10.1159/000350479. Epub 2013 Jun 28.
Much more than mechanical biofilm removal, toothbrushing with fluoride toothpastes is an effective way of increasing the availability of fluoride in the oral cavity to reduce demineralization and enhance remineralization of enamel and dentine. These effects of fluoride toothpastes have been estimated by a wide range of laboratory and human studies, which have helped to develop anticaries effective formulations and understand their mechanism of action. These studies have focused on the availability of fluoride in the toothpaste formulations, its bioavailability in saliva and remnants of disturbed biofilm, its reaction with the dental substrate to form loosely bound reservoirs as well as the ultimate reduction of mineral loss and increase in mineral and fluoride content of caries lesions. The specifics of these modes of action and their application in in vitro, in situ and in vivo preclinical tests is presented and discussed.
使用含氟牙膏刷牙不仅仅是机械性地去除牙菌斑，更是一种有效增加口腔中氟化物可利用性的方法，以减少牙齿脱矿并增强牙釉质和牙本质的再矿化。含氟牙膏的这些作用已通过广泛的实验室研究和人体研究进行了评估，这些研究有助于开发防龋有效配方并了解其作用机制。这些研究集中在牙膏配方中氟化物的可利用性、其在唾液和受干扰牙菌斑残余物中的生物利用度、其与牙齿基质的反应以形成松散结合的储存库，以及最终减少矿物质流失和增加龋损部位的矿物质和氟含量。本文介绍并讨论了这些作用方式的具体情况及其在体外、原位和体内临床前试验中的应用。
