Grodzinska L, Panczenko B, Gryglewski R J
J Pharm Pharmacol. 1975 Feb;27(2):88-91. doi: 10.1111/j.2042-7158.1975.tb09414.x.
Challenges of the superfused (1 ml min-1) trachea with histamine (100-200 mug) result in the release of prostaglandin E-like material (3-25 ng in terms of prostaglandin E2) but no prostaglandin F-like activity has been detected in the superfusate. This release is blocked by indomethacin (1mug ml-1) and then the contractile action of histamine is enhanced. It is concluded that the release of a prostaglandin E-like material by histamine from tracheal smooth muscles is a self-defensive mechanism protecting against the strong constriction of airways. The maximal relaxation of trachea by isoprenaline (50-500 mug) is not accompanied by the release of a prostaglandin-like material.
用组胺（100 - 200微克）对灌注速率为1毫升/分钟的气管进行刺激，会导致类前列腺素E物质的释放（以前列腺素E2计为3 - 25纳克），但在灌注液中未检测到类前列腺素F活性。吲哚美辛（1微克/毫升）可阻断这种释放，随后组胺的收缩作用增强。由此得出结论，组胺从气管平滑肌释放类前列腺素E物质是一种自我防御机制，可防止气道强烈收缩。异丙肾上腺素（50 - 500微克）使气管最大程度舒张时，并未伴随类前列腺素样物质的释放。
