de Arruda Joana Soares, Araujo Júnior Edward, Simões Manuel de Jesus, Kulay Júnior Luiz
Department of Obstetrics, Federal University of São Paulo (UNIFESP), Rua Carlos Weber, 956 Apartment 113 Visage, Vila Leopoldina, 05303-000 São Paulo, SP, Brazil.
J Pregnancy. 2013;2013:213193. doi: 10.1155/2013/213193. Epub 2013 Jun 2.
To assess the concentration of progesterone (PRs) and oestrogen (ORs) receptors of myometrium of full-term pregnant women in the myometrium of lower segment of the uterus in relationship with presence or absence of labour.
This was a cross-sectional prospective study with 21 pregnant women, being 6 in labour (Group I) and 15 without labour (Group II). The biopsy of myometrium was realized during caesarian section, and the excised tissue was stained using immunohistochemical techniques for the quantification of the receptors, and with the aid of image-analysis software, the numbers of receptors for each hormone were determined spectrophotometrically. The Mann-Whitney test was used to compare the pregnant women in each study group with respect to the numbers of ORs and PRs. The Wilcoxon test was used to compare the concentration of ORs and PRs in each group separately.
The mean of gestational age was 39 weeks, (range, 37 to 41 weeks). The medians of PRs and ORs in pregnant women in labour (Group I) were 29.3 (range, 24.6-30.2) and 32.3 (range, 22.9-49.0), respectively. The medians of PRs and ORs in pregnant women without labour (Group II) were 43.6 (range, 23.6-70) and 43.9 (range, 18.3-62.6), respectively. We did not observe significant differences of the number of ORs and PRs in both groups (P = 0.13 and 0.37, resp.). The number of ORs was statistically more than that of PRs in Group II (Z calculated = 16.00).
The concentrations of PRs and ORs were similar in the myometrium of the lower uterine segment of pregnant women during and without labour, but the concentration of ORs was more than that of PRs in the myometrium of the lower uterine segment of pregnant women without labour.
评估足月孕妇子宫下段肌层中孕酮（PRs）和雌激素（ORs）受体的浓度与是否临产的关系。
这是一项横断面前瞻性研究，有21名孕妇，其中6名临产（I组），15名未临产（II组）。在剖宫产术中进行子宫肌层活检，切除的组织采用免疫组织化学技术染色以定量受体，并借助图像分析软件，通过分光光度法测定每种激素的受体数量。采用曼-惠特尼检验比较各研究组孕妇的ORs和PRs数量。采用威尔科克森检验分别比较每组中ORs和PRs的浓度。
平均孕周为39周（范围37至41周）。临产孕妇（I组）的PRs和ORs中位数分别为29.3（范围24.6 - 30.2）和32.3（范围22.9 - 49.0）。未临产孕妇（II组）的PRs和ORs中位数分别为43.6（范围23.6 - 70）和43.9（范围18.3 - 62.6）。我们未观察到两组中ORs和PRs数量有显著差异（P值分别为0.13和0.37）。II组中ORs数量在统计学上多于PRs数量（计算得到的Z值 = 16.00）。
临产和未临产孕妇子宫下段肌层中PRs和ORs的浓度相似，但未临产孕妇子宫下段肌层中ORs的浓度高于PRs。
