Rezapour M, Bäckström T, Lindblom B, Ulmsten U
Department of Obstetrics and Gynecology, University of Uppsala, Sweden.
Obstet Gynecol. 1997 Jun;89(6):918-24. doi: 10.1016/s0029-7844(97)00116-6.
To investigate the correlation between sex steroid hormones and their receptors during normal and dysfunctional labor.
Myometrial and decidual biopsies along with maternal and cord blood samples were taken from women with or without labor activity. Estrogen and progesterone receptor contents in myometrium and decidua were determined by enzyme immunoassay, and hormone concentrations were analyzed by radioimmunoassay.
In the lower segment of the uterus, the progesterone receptor concentrations of myometrium were significantly lower in oxytocin-resistant dystocia compared with those of normal labor and before labor (P < .04, P < .005, respectively). No significant difference was found in the estrogen receptors contents in the groups studied. The progesterone receptors of myometrium from the upper segment showed higher concentrations in active labor compared with those before labor and oxytocin-resistant labor (P <.01, P < .05, respectively). Estrogen receptors from the upper segment showed no significant difference in these regards. There was no difference in peripheral and myometrial sex hormone levels in the groups studied.
These data suggest that, in the human, 1) oxytocin-resistant labor is associated with low levels of progesterone receptors, 2) estrogen receptors content in myometrium might have no or little relation to labor, and 3) functional labor seems not to be related to a decreased progesterone activity in the myometrium.
探讨正常分娩与难产过程中性类固醇激素及其受体之间的相关性。
采集有或无分娩活动的女性的子宫肌层和蜕膜组织活检样本以及母体和脐带血样本。采用酶免疫分析法测定子宫肌层和蜕膜中雌激素和孕激素受体含量，采用放射免疫分析法分析激素浓度。
在子宫下段，与正常分娩及临产前相比，宫缩乏力性难产患者子宫肌层孕激素受体浓度显著降低（分别为P <.04，P <.005）。在所研究的组中，雌激素受体含量未发现显著差异。与临产前及宫缩乏力性分娩相比，活跃期分娩患者子宫上段肌层孕激素受体浓度较高（分别为P <.01，P <.05）。子宫上段雌激素受体在这些方面未显示出显著差异。在所研究的组中，外周血和子宫肌层性激素水平无差异。
这些数据表明，在人类中，1）宫缩乏力性分娩与孕激素受体水平低有关，2）子宫肌层雌激素受体含量可能与分娩无关或关系不大，3）正常分娩似乎与子宫肌层孕激素活性降低无关。
