Suzuki Takahisa, Furuse Hiroshi, Kurita Yutaka, Imanishi Takeshi, Tamura Keita, Otsuka Atsushi, Mugiya Soichi, Ozono Seiichiro
Department of Urology, Hamamatsu University School of Medicine.
Nihon Hinyokika Gakkai Zasshi. 2013 May;104(3):549-53. doi: 10.5980/jpnjurol.104.549.
We report a case of clear cell adenocarcinoma of the female urethra. A 57-year-old woman presented with complaint of gross hematuria. Abdominal ultrasonography, cystourethroscopy, computed tomography (CT) and magnetic resonance imaging (MRI) revealed the urethral tumor was invasive to bladder neck. Clinical stage was determined as cT3N1M0, then anterior pelvic exenteration and ileal conduit formation were performed. The pathological diagnosis was clear cell adenocarcinoma of urethra and the stage was pT3N1. The patient received TS-1 and cisplatin for postoperative recurrence, but she died from multiple lung metastasis 54 months after the operation. Clear cell adenocarcinoma of the female urethra is rare case in the Japanese literatures. Pathogenesis and management of this rare condition are discussed.
我们报告一例女性尿道透明细胞腺癌。一名57岁女性因肉眼血尿就诊。腹部超声、膀胱尿道镜检查、计算机断层扫描（CT）和磁共振成像（MRI）显示尿道肿瘤侵犯膀胱颈。临床分期确定为cT3N1M0，随后进行了前盆腔脏器清除术和回肠代膀胱术。病理诊断为尿道透明细胞腺癌，分期为pT3N1。患者术后复发接受替吉奥（TS-1）和顺铂治疗，但术后54个月死于多发肺转移。女性尿道透明细胞腺癌在日本文献中为罕见病例。本文讨论了这种罕见疾病的发病机制和治疗方法。
