Department of Chemistry, Keio University, 3-14-1 Hiyoshi, Yokohama, 223-8522, Japan.
Org Lett. 2013 Jul 19;15(14):3710-3. doi: 10.1021/ol401571r. Epub 2013 Jul 2.
Although 4-hydroxyquinolin-2(1H)-one derivatives have attracted much attention due to their biological benefits, conventional reactions under harsh heat conditions must be employed to provide these key compounds. In the presence of a catalytic amount of silver salt, various o-alkynylanilines were treated with carbon dioxide and a base under mild reaction conditions to afford the corresponding 4-hydroxyquinolin-2(1H)-one derivatives in high yield.
尽管 4-羟基喹啉-2(1H)-酮衍生物因其生物益处而受到广泛关注，但必须采用苛刻的热条件下的常规反应来提供这些关键化合物。在催化量的银盐存在下，各种邻炔基苯胺在温和的反应条件下与二氧化碳和碱反应，以高产率得到相应的 4-羟基喹啉-2(1H)-酮衍生物。
