Department of Urology, Kunming General Hospital of Chengdu Military Command, Kunming 650032, China.
Diagn Pathol. 2013 Jul 2;8:112. doi: 10.1186/1746-1596-8-112.
Numerous epidemiological studies have been conducted to explore the association between the Lys939Gln polymorphism of Xeroderma pigmentosum group C (XPC) gene and urinary bladder cancer susceptibility. However, the results remain inconclusive. In order to derive a more precise estimation of this relationship, a large and update meta-analysis was performed in this study.
A comprehensive search was conducted through researching MEDLINE, EMBASE, PubMed, Web of Science, China Biomedical Literature database (CBM) and China National Knowledge Infrastructure (CNKI) databases before June 2013. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of the association.
A total of 12 studies with 4828 cases and 4890 controls for evaluating the XPC Lys939Gln polymorphism and urinary bladder cancer were included. Overall, there was significant associations between the XPC Lys939Gln polymorphism and urinary bladder cancer risk were found for homozygous model (OR = 1.352, 95% CL = 1.088-1.681), heterozygous model (OR = 1.354, 95% CL = 1.085-1.688), and allele comparison (OR = 1.109, 95% CL = 1.013-1.214). In subgroup analysis by ethnicity and source of controls, there were still significant associations detected in some genetic models.
Our meta-analysis suggested that the XPC Lys939Gln polymorphism contributed to the risk of urinary bladder cancer.
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1001118393101798.
已经有许多流行病学研究探索了着色性干皮病 C 组（XPC）基因 Lys939Gln 多态性与膀胱癌易感性之间的关系。然而，结果并不一致。为了更准确地评估这种关系，本研究进行了一项大型的更新荟萃分析。
通过检索 MEDLINE、EMBASE、PubMed、Web of Science、中国生物医学文献数据库（CBM）和中国国家知识基础设施（CNKI）数据库，对截至 2013 年 6 月的相关研究进行了全面搜索。使用粗比值比（OR）及其 95%置信区间（CI）来评估关联的强度。
共纳入了 12 项研究，包含 4828 例病例和 4890 例对照，用于评估 XPC Lys939Gln 多态性与膀胱癌的关系。总体而言，XPC Lys939Gln 多态性与膀胱癌风险之间存在显著关联，无论是在纯合子模型（OR=1.352，95%CI=1.088-1.681）、杂合子模型（OR=1.354，95%CI=1.085-1.688）还是等位基因比较（OR=1.109，95%CI=1.013-1.214）中均是如此。按种族和对照来源进行亚组分析，仍发现某些遗传模型存在显著关联。
本荟萃分析提示 XPC Lys939Gln 多态性与膀胱癌风险相关。
Zotero 插件
