Brzezińska-Wcisło L
I Katedry i Kliniki Dermatologii Sl. AM w Katowicach.
Przegl Dermatol. 1990 Jan-Feb;77(1):14-9.
In the trichological studies on the model of Wistar rats aged 4-5 weeks intraperitoneal vinblastine in doses of 0.008-0.030 mg/100 g of body weight caused initially mixed (dystrophic-telogenic) hair loss. After higher doses and longer drug administration the mechanism of hair loss was transformed to dystrophic. In both forms of hair loss signs of advanced diffuse alopecia were found.
在对4-5周龄Wistar大鼠模型进行的毛发学研究中，腹腔注射剂量为0.008-0.030毫克/100克体重的长春碱最初会导致混合性（营养不良-休止期）脱发。在使用更高剂量并延长给药时间后，脱发机制转变为营养不良性。在这两种脱发形式中均发现了晚期弥漫性脱发的迹象。
