Brzezińska-Wcisło L
Przegl Dermatol. 1989 Jan-Mar;76(1):33-8.
In investigations on Wistar rats aged 4-5 weeks it was found that intraperitoneal administration of Bleomycin in doses from 0.015 to 0.045 mg/100 g of body weight caused disturbances of hair growth. Initially hair loss had a telogenic mechanism, and after higher doses administered for longer time periods it changed to poorly evidenced alopecia with a dystrophic-telogenic pathological mechanism, without clinical signs of fur thinning.
在对4-5周龄的Wistar大鼠进行的研究中发现,腹腔注射剂量为0.015至0.045毫克/100克体重的博来霉素会导致毛发生长紊乱。最初,脱发具有休止期机制,在长时间给予更高剂量后,脱发转变为营养不良性休止期病理机制的明显脱发,且无毛发变稀的临床症状。