Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, 250021, China; The Key laboratory for Reproductive Endocrinology of Ministry of Education, 250021, China; Shandong Provincial Key Laboratory of Reproductive Medicine, 324 Jingwu Road, Jinan 250021, China.
Eur J Obstet Gynecol Reprod Biol. 2013 Sep;170(1):162-4. doi: 10.1016/j.ejogrb.2013.06.002. Epub 2013 Jun 29.
A state of systemic chronic low grade inflammation has been observed in polycystic ovary syndrome (PCOS). It has been suggested that inflammation is a potential mechanism influencing the ovaries or endocrine system and might therefore contribute to the pathophysiology of PCOS. The aim of this study was to compare the total white blood cell (WBC), neutrophil granulocyte and lymphocyte differential counts between women with PCOS and controls. In addition, we estimated if the WBC differential counts had a relationship with body mass index (BMI), total testosterone levels, estradiol levels and luteinizing hormone levels of women with PCOS.
1016 subjects with PCOS and 1016 age-matched healthy women from a Han Chinese population were enrolled in this case-control study. Blood samples were taken from all the patients and controls to test total WBC counts, lymphocyte counts, neutrophil counts and related serum hormones.
Total WBC counts and lymphocyte counts were elevated in PCOS subjects (t-test P<0.01). Higher lymphocyte counts which contributed to higher total WBC counts in PCOS women were compared to age-matched controls. When the data were adjusted by BMI, the difference of WBC counts and lymphocyte counts between patients and controls remained significant.
The state of chronic low grade inflammation in patients with PCOS might be associated with immunological factors. Obesity and hyperandrogenism may be due to the underlying low grade inflammation.
多囊卵巢综合征（PCOS）患者存在全身慢性低度炎症状态。有研究表明，炎症可能是影响卵巢或内分泌系统的潜在机制，并可能导致 PCOS 的病理生理学发生变化。本研究旨在比较 PCOS 患者与对照组之间的总白细胞（WBC）、中性粒细胞和淋巴细胞分类计数。此外，我们还评估了 WBC 分类计数与 PCOS 患者的体重指数（BMI）、总睾酮水平、雌二醇水平和黄体生成素水平是否存在相关性。
本病例对照研究纳入了 1016 例 PCOS 患者和 1016 例年龄匹配的汉族健康女性。从所有患者和对照组采集血样，检测总 WBC 计数、淋巴细胞计数、中性粒细胞计数和相关血清激素。
PCOS 患者的总 WBC 计数和淋巴细胞计数升高（t 检验 P<0.01）。与年龄匹配的对照组相比，PCOS 女性的淋巴细胞计数更高，导致总 WBC 计数更高。当按 BMI 调整数据时，患者和对照组之间的 WBC 计数和淋巴细胞计数差异仍然显著。
PCOS 患者的慢性低度炎症状态可能与免疫因素有关。肥胖和高雄激素血症可能是潜在低度炎症的结果。
