Department of Infertility Clinic, Yulin City First Hospital, Yulin, China.
Department of Gynecology, Northwest Women and Children's Hospital, Xi'an, China.
Reprod Sci. 2023 Feb;30(2):633-641. doi: 10.1007/s43032-022-01030-w. Epub 2022 Jul 21.
To explore the associations of alanine aminotransferase in lean women of polycystic ovary syndrome (PCOS) with other biochemical parameters and the potential risk factors. This is a retrospective cohort study with lean PCOS (n = 91) and healthy controls (n = 45); we reviewed the electrical records and databases of the PCOS patients in our infertility clinic between January 2019 and September 2021; independent t-test, linear correlation analysis, and multiple linear regression were used to explore the associations. Higher levels of luteinizing hormone, total testosterone, thyroid stimulating hormone, platelet count, lymphocyte count, homocysteine, alanine aminotransferase (ALT), and uric acid were identified in lean PCOS patients, while follicle-stimulating hormone level was lower in in lean PCOS as expected (P < 0.05). Of note, the linear correlation showed that BMI, total testosterone, white blood cell count, lymphocyte count, aspartate aminotransferase, and uric acid were positively associated with alanine aminotransferase (r = 0.232, 0.318, 0.218, 0.388, 0.602, 0.353 respectively, P < 0.05). After multiple linear regression was performed, total testosterone and aspartate aminotransferase were independently and positively correlated with alanine aminotransferase in lean PCOS (B = 0.251, 0.605 respectively, P < 0.05). Higher level of ALT was identified in the lean PCOS. BMI, white blood cell count, lymphocyte count, aspartate aminotransferase, uric acid, and total testosterone were positively correlated with ALT in lean PCOS. Total testosterone and aspartate aminotransferase were independently and positively associated with ALT in lean PCOS after multiple linear regression. There might exist a potential risk of afflicting liver impairment for the lean PCOS women in the earlier period. Early examination and intervention might be necessary to prevent or delay the progression of the liver disease as soon as the diagnosis of PCOS.
探讨瘦型多囊卵巢综合征（PCOS）女性丙氨酸氨基转移酶（ALT）与其他生化参数及潜在危险因素的相关性。这是一项回顾性队列研究，纳入瘦型 PCOS 患者（n=91）和健康对照者（n=45）；我们回顾了 2019 年 1 月至 2021 年 9 月期间我院不孕不育科 PCOS 患者的电子病历和数据库；采用独立 t 检验、线性相关分析和多元线性回归来探讨相关性。瘦型 PCOS 患者黄体生成素（LH）、总睾酮（TT）、促甲状腺激素（TSH）、血小板计数、淋巴细胞计数、同型半胱氨酸、ALT 和尿酸水平较高，而预期的卵泡刺激素（FSH）水平较低（P<0.05）。值得注意的是，线性相关显示 BMI、TT、白细胞计数、淋巴细胞计数、天门冬氨酸氨基转移酶（AST）和尿酸与 ALT 呈正相关（r=0.232、0.318、0.218、0.388、0.602、0.353，均 P<0.05）。多元线性回归分析显示，TT 和 AST 与瘦型 PCOS 患者的 ALT 呈独立且正相关（B=0.251、0.605，均 P<0.05）。瘦型 PCOS 患者的 ALT 水平较高。BMI、白细胞计数、淋巴细胞计数、AST、尿酸和 TT 与瘦型 PCOS 患者的 ALT 呈正相关。多元线性回归分析显示，TT 和 AST 与瘦型 PCOS 患者的 ALT 呈独立且正相关。瘦型 PCOS 患者可能存在早期肝损伤的潜在风险。一旦诊断为 PCOS，应尽早进行检查和干预，以预防或延缓肝病的进展。
