Böhmer M M, Hellenbrand W, Matysiak-Klose D, Heininger U, Müters S, Wichmann O
Fachgebiet Impfprävention, Robert Koch-Institut, Berlin, Germany.
Dtsch Med Wochenschr. 2013 Jul;138(28-29):1451-7. doi: 10.1055/s-0033-1343249. Epub 2013 Jul 2.
Pertussis vaccination for risk-groups (e. g. healthcare workers, employees of communal facilities, or persons with close contact to infants) has been recommended in Germany since 2001. In 2009, single-dose acellular pertussis (ap) vaccination was recommended for all adults at the next tetanus-diphtheria (Td) booster. Study aims were to assess 1) pertussis vaccination coverage in adults, and 2) use of tetanus-containing combination vaccines in hospitals.
For 1) we analysed data from two population-based telephone surveys conducted among adults in Germany in 2009/2010 (GEDA09: n = 21,262; GEDA10: n = 22,050). Factors associated with vaccination were identified by logistic regression analyses. For 2) a questionnaire survey of 133 hospital pharmacies serving 454 German hospitals was undertaken for the year 2007.
Overall, 5.9% (95% confidence interval [CI] 5.5-6.3%) of GEDA10 participants reported up-to-date pertussis vaccination (ap-vaccination in past 10 years). In risk-groups, vaccination coverage was 10.7% (95%-CI 9.8-11.7%). Residence in former East-Germany and younger age were independently associated with an adequate vaccination status. Contrary to prevailing recommendations, ~75% of tetanus vaccines were administered as monovalent rather than Td- (or Tdap-)combination vaccines in hospitals.
In light of high pertussis-incidence and low vaccination coverage in German adults, improvement of pertussis vaccine uptake is vital, e. g. through awareness campaigns targeting both physicians in private practice and hospitals.
自2001年起,德国就建议对高危人群(如医护人员、公共设施工作人员或与婴儿密切接触的人员)接种百日咳疫苗。2009年,建议所有成年人在下次破伤风 - 白喉(Td)加强免疫时接种单剂量无细胞百日咳(ap)疫苗。研究目的是评估:1)成人百日咳疫苗接种率;2)医院中含破伤风联合疫苗的使用情况。
对于1),我们分析了2009/2010年在德国成年人中进行的两项基于人群的电话调查数据(GEDA09:n = 21,262;GEDA10:n = 22,050)。通过逻辑回归分析确定与疫苗接种相关的因素。对于2),在2007年对为454家德国医院服务的133家医院药房进行了问卷调查。
总体而言,GEDA10参与者中有5.9%(95%置信区间[CI] 5.5 - 6.3%)报告已接种最新的百日咳疫苗(过去10年内接种ap疫苗)。在高危人群中,疫苗接种率为10.7%(95%-CI 9.8 - 11.7%)。居住在前东德地区和较年轻年龄与充足的疫苗接种状态独立相关。与现行建议相反,在医院中约75%的破伤风疫苗作为单价疫苗而非Td(或Tdap)联合疫苗给药。
鉴于德国成年人百日咳发病率高且疫苗接种率低,提高百日咳疫苗接种率至关重要,例如通过针对私人执业医生和医院开展宣传活动。