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[德国成年人的百日咳疫苗接种覆盖率]

[Pertussis vaccination coverage among adults in Germany].

作者信息

Böhmer M M, Hellenbrand W, Matysiak-Klose D, Heininger U, Müters S, Wichmann O

机构信息

Fachgebiet Impfprävention, Robert Koch-Institut, Berlin, Germany.

出版信息

Dtsch Med Wochenschr. 2013 Jul;138(28-29):1451-7. doi: 10.1055/s-0033-1343249. Epub 2013 Jul 2.

Abstract

BACKGROUND

Pertussis vaccination for risk-groups (e. g. healthcare workers, employees of communal facilities, or persons with close contact to infants) has been recommended in Germany since 2001. In 2009, single-dose acellular pertussis (ap) vaccination was recommended for all adults at the next tetanus-diphtheria (Td) booster. Study aims were to assess 1) pertussis vaccination coverage in adults, and 2) use of tetanus-containing combination vaccines in hospitals.

METHODS

For 1) we analysed data from two population-based telephone surveys conducted among adults in Germany in 2009/2010 (GEDA09: n = 21,262; GEDA10: n = 22,050). Factors associated with vaccination were identified by logistic regression analyses. For 2) a questionnaire survey of 133 hospital pharmacies serving 454 German hospitals was undertaken for the year 2007.

RESULTS

Overall, 5.9% (95% confidence interval [CI] 5.5-6.3%) of GEDA10 participants reported up-to-date pertussis vaccination (ap-vaccination in past 10 years). In risk-groups, vaccination coverage was 10.7% (95%-CI 9.8-11.7%). Residence in former East-Germany and younger age were independently associated with an adequate vaccination status. Contrary to prevailing recommendations, ~75% of tetanus vaccines were administered as monovalent rather than Td- (or Tdap-)combination vaccines in hospitals.

CONCLUSIONS

In light of high pertussis-incidence and low vaccination coverage in German adults, improvement of pertussis vaccine uptake is vital, e. g. through awareness campaigns targeting both physicians in private practice and hospitals.

摘要

背景

自2001年起,德国就建议对高危人群(如医护人员、公共设施工作人员或与婴儿密切接触的人员)接种百日咳疫苗。2009年,建议所有成年人在下次破伤风 - 白喉(Td)加强免疫时接种单剂量无细胞百日咳(ap)疫苗。研究目的是评估:1)成人百日咳疫苗接种率;2)医院中含破伤风联合疫苗的使用情况。

方法

对于1),我们分析了2009/2010年在德国成年人中进行的两项基于人群的电话调查数据(GEDA09:n = 21,262;GEDA10:n = 22,050)。通过逻辑回归分析确定与疫苗接种相关的因素。对于2),在2007年对为454家德国医院服务的133家医院药房进行了问卷调查。

结果

总体而言,GEDA10参与者中有5.9%(95%置信区间[CI] 5.5 - 6.3%)报告已接种最新的百日咳疫苗(过去10年内接种ap疫苗)。在高危人群中,疫苗接种率为10.7%(95%-CI 9.8 - 11.7%)。居住在前东德地区和较年轻年龄与充足的疫苗接种状态独立相关。与现行建议相反,在医院中约75%的破伤风疫苗作为单价疫苗而非Td(或Tdap)联合疫苗给药。

结论

鉴于德国成年人百日咳发病率高且疫苗接种率低,提高百日咳疫苗接种率至关重要,例如通过针对私人执业医生和医院开展宣传活动。

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