Nauta R J, Tsimoyiannis E, Uribe M, Walsh D B, Miller D, Butterfield A
Department of Surgery, Georgetown University Hospital, Washington, District of Columbia.
Surg Gynecol Obstet. 1990 Aug;171(2):120-5.
We have previously described a chronic, in vivo biochemical and histologic model of ischemia and reperfusion injury and wished to test the ability of superoxide dismutase, catalase and allopurinol to protect against the hepatocellular injury demonstrated by this model. Xanthine oxidase inhibitors given preoperatively produced a significant hepatocellular protective effect when compared with a comparable insult delivered to a cohort of control rats. The protection given seemed greater than that produced by pretreatment with free radical scavengers. Possible mechanisms for this observation are discussed. Investigations combining free radical scavengers with xanthine oxidase inhibitors may further define protection for warm hepatic ischemia and reperfusion injury.
我们之前描述过一种慢性的、体内缺血再灌注损伤的生化和组织学模型，并希望测试超氧化物歧化酶、过氧化氢酶和别嘌呤醇预防该模型所显示的肝细胞损伤的能力。与给予一组对照大鼠的类似损伤相比，术前给予黄嘌呤氧化酶抑制剂可产生显著的肝细胞保护作用。所给予的保护作用似乎大于自由基清除剂预处理所产生的保护作用。本文讨论了这一观察结果的可能机制。将自由基清除剂与黄嘌呤氧化酶抑制剂联合进行的研究可能会进一步明确对肝脏热缺血再灌注损伤的保护作用。
