三种口服多剂量给药方案后支气管黏膜和痰液中头孢克肟的浓度。
Concentrations of cefixime in bronchial mucosa and sputum after three oral multiple dose regimens.
作者信息
Baldwin D R, Andrews J M, Ashby J P, Wise R, Honeybourne D
机构信息
Department of Thoracic Medicine, Dudley Road Hospital, Birmingham.
出版信息
Thorax. 1990 May;45(5):401-2. doi: 10.1136/thx.45.5.401.
Abstract
In a study of 58 patients the concentrations of cefixime, a new oral cephem antibiotic, in bronchial mucosa were 35-40% of the concentrations found in simultaneously collected serum samples. The antibiotic was often undetectable in sputum despite a highly sensitive assay.
摘要
在一项针对58名患者的研究中，新型口服头孢菌素类抗生素头孢克肟在支气管黏膜中的浓度为同时采集的血清样本中浓度的35%-40%。尽管检测方法高度灵敏，但该抗生素在痰液中常常检测不到。
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