Chawla Raman, Thakur Pallavi, Chowdhry Ayush, Jaiswal Sarita, Sharma Anamika, Goel Rajeev, Sharma Jyoti, Priyadarshi Smruti Sagar, Kumar Vinod, Sharma Rakesh Kumar, Arora Rajesh
Office of CC R&D (LS & IC), Defence Research and Development Organisation, DRDO Bhawan, New Delhi, India.
J Diabetes Metab Disord. 2013 Jul 4;12(1):35. doi: 10.1186/2251-6581-12-35.
Plants by virtue of its composition of containing multiple constituents developed during its growth under various environmental stresses providing a plethora of chemical families with medicinal utility. Researchers are exploring this wealth and trying to decode its utility for enhancing health standards of human beings. Diabetes is dreadful lifestyle disorder of 21st century caused due to lack of insulin production or insulin physiological unresponsiveness. The chronic impact of untreated diabetes significantly affects vital organs. The allopathic medicines have five classes of drugs, or otherwise insulin in Type I diabetes, targeting insulin secretion, decreasing effect of glucagon, sensitization of receptors for enhanced glucose uptake etc. In addition, diet management, increased food fiber intake, Resistant Starch intake and routine exercise aid in managing such dangerous metabolic disorder. One of the key factors that limit commercial utility of herbal drugs is standardization. Standardization poses numerous challenges related to marker identification, active principle(s), lack of defined regulations, non-availability of universally acceptable technical standards for testing and implementation of quality control/safety standard (toxicological testing). The present study proposed an integrated herbal drug development & standardization model which is an amalgamation of Classical Approach of Ayurvedic Therapeutics, Reverse Pharmacological Approach based on Observational Therapeutics, Technical Standards for complete product cycle, Chemi-informatics, Herbal Qualitative Structure Activity Relationship and Pharmacophore modeling and, Post-Launch Market Analysis. Further studies are warranted to ensure that an effective herbal drug standardization methodology will be developed, backed by a regulatory standard guide the future research endeavors in more focused manner.
植物因其在各种环境胁迫下生长过程中所含的多种成分，形成了大量具有药用价值的化学类别。研究人员正在探索这一宝库，并试图解读其对提高人类健康水平的效用。糖尿病是21世纪一种可怕的生活方式紊乱疾病，是由于胰岛素分泌不足或胰岛素生理反应不敏感所致。未经治疗的糖尿病的慢性影响会严重影响重要器官。对抗疗法的药物有五类，或者在I型糖尿病中使用胰岛素，其作用靶点包括胰岛素分泌、降低胰高血糖素的作用、使受体敏感以增强葡萄糖摄取等。此外，饮食管理、增加膳食纤维摄入量、抗性淀粉摄入量和日常锻炼有助于控制这种危险的代谢紊乱。限制草药商业效用的关键因素之一是标准化。标准化带来了许多挑战，涉及标志物鉴定、活性成分、缺乏明确的法规、缺乏普遍可接受的检测技术标准以及质量控制/安全标准（毒理学检测）的实施。本研究提出了一种综合的草药研发与标准化模型，它融合了阿育吠陀疗法的经典方法、基于观察疗法的反向药理学方法、完整产品周期的技术标准、化学信息学、草药定性构效关系和药效团建模以及上市后市场分析。有必要进行进一步的研究，以确保开发出一种有效的草药标准化方法，并以监管标准为后盾，更有针对性地指导未来的研究工作。
