European Molecular Biology Laboratory Heidelberg, Heidelberg, Germany.
Biophys J. 2013 Jul 2;105(1):3-10. doi: 10.1016/j.bpj.2013.05.039.
The invagination of the mesoderm in the Drosophila melanogaster embryo is an intensely studied example of epithelial folding. Several theoretical studies have explored the conditions and mechanisms needed to reproduce the formation of the invagination in silico. Here we discuss the aspects of epithelial folding captured by these studies, and compare the questions addressed, the approaches used, and the answers provided.
果蝇胚胎中中胚层的内陷是上皮折叠的一个被深入研究的范例。有几项理论研究探索了在计算机中再现内陷形成所需的条件和机制。在这里,我们讨论了这些研究所捕捉到的上皮折叠的各个方面,并比较了所研究的问题、所采用的方法和所提供的答案。