氚化河豚毒素与乌贼巨大轴突的结合。
The binding of tritiated tetrodotoxin to squid giant axons.
作者信息
Levinson S R, Meves H
出版信息
Philos Trans R Soc Lond B Biol Sci. 1975 Jun 10;270(908):349-52. doi: 10.1098/rstb.1975.0014.
PMID:238233
Abstract
The binding of tetrodotoxin to squid gian axons was determined as a function of toxin concentration, using a tritiated toxin preparation of known radiochemical purity and specific activity. From the amount of saturable binding observed, the number of toxin binding sites thought to be sodium channels was found to be 553 plus or minus 119/mum-2 of axon surface.
摘要
利用具有已知放射化学纯度和比活性的氚化毒素制剂，测定了河豚毒素与鱿鱼巨轴突的结合情况，并将其作为毒素浓度的函数。根据观察到的可饱和结合量，发现被认为是钠通道的毒素结合位点数量为轴突表面每平方微米553±119个。
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