Ngomuo A J, Kassuku A A, Ruheta M R
Faculty of Veterinary Medicine, Sokoine University of Agriculture, Morogoro, Tanzania.
Vet Parasitol. 1990 May;36(1-2):21-6. doi: 10.1016/0304-4017(90)90090-x.
Following reports of suspected gastrointestinal strongylid nematode resistance to thiophanate in sheep and goats at Sokoine University of Agriculture (SUA), Tanzania, field strains of Haemonchus contortus, one from SUA and another from Kimamba, Tanzania, were selected for a critical controlled test to evaluate the efficacy of thiophanate. The SUA H. contortus strain in goats showed a marked resistance to thiophanate at an oral dose of 50 mg kg-1 liveweight (efficacy = 24.1%), while the Kimamba H. contortus strain showed very marked susceptibility (efficacy = 99.7%) to thiophanate at the same oral dose. This is the first report from East Africa of a field strain of H. contortus resistant to thiophanate. The incidence of resistant strains of strongyloid parasites to benzimidazole anthelmintics in sheep and goats in East Africa is on the increase. The magnitude of this problem should be evaluated and remedial solutions sought.
在坦桑尼亚索科因大学（SUA）有报告称，绵羊和山羊体内的胃肠道圆线虫疑似对甲基托布津产生耐药性之后，从坦桑尼亚的SUA和金马巴选取了捻转血矛线虫的田间菌株，进行了一项关键对照试验，以评估甲基托布津的疗效。在山羊体内，SUA的捻转血矛线虫菌株在口服剂量为50毫克/千克体重时对甲基托布津表现出明显耐药性（疗效 = 24.1%），而金马巴的捻转血矛线虫菌株在相同口服剂量下对甲基托布津表现出极高的敏感性（疗效 = 99.7%）。这是东非首次报告捻转血矛线虫田间菌株对甲基托布津耐药。东非绵羊和山羊体内的类圆线虫寄生虫对苯并咪唑驱虫药的耐药菌株发生率正在上升。应评估这一问题的严重程度并寻求补救办法。
