Borgsteede F H, Duyn S P
Department of Parasitology, Central Veterinary Institute, AB Lelystad, The Netherlands.
Res Vet Sci. 1989 Sep;47(2):270-2.
The resistance level of Haemonchus contortus was studied on a farm where benzimidazole resistance had been detected in 1980 and where, since 1982, only levamisole had been used for worm control. Egg development tests gave LD50 values of 0.18, 0.19 and 0.21 microgram ml-1 thiabendazole for samples taken from ewes in 1988 compared with 0.21 microgram ml-1 in 1981. Studies on sheep experimentally infected with larvae cultured from the faeces of these ewes confirmed the continued resistance of H contortus to benzimidazoles, and demonstrated the absence of benzimidazole resistance in other nematode species together with the susceptibility of all species to levamisole.
在一个农场对捻转血矛线虫的抗药水平进行了研究。该农场于1980年检测到对苯并咪唑有抗性，自1982年以来仅使用左旋咪唑进行蠕虫控制。卵发育试验得出，1988年从母羊采集的样本中，噻苯达唑的半数致死剂量（LD50）值分别为0.18、0.19和0.21微克/毫升，而1981年为0.21微克/毫升。对用这些母羊粪便培养的幼虫进行实验性感染的绵羊研究证实，捻转血矛线虫对苯并咪唑持续具有抗性，同时表明其他线虫种类不存在苯并咪唑抗性，且所有种类对左旋咪唑敏感。
