使用超极化磁共振波谱技术体外可视化甜菜醛的合成和氧化。

In vitro visualization of betaine aldehyde synthesis and oxidation using hyperpolarized magnetic resonance spectroscopy.

机构信息

Department of Radiology, Hadassah-Hebrew University Medical Center, Jerusalem, 91120, Israel.

出版信息

Chem Commun (Camb). 2013 Aug 14;49(63):7076-8. doi: 10.1039/c3cc42542h.

Abstract

Real-time monitoring of betaine aldehyde metabolism at high temporal resolution was accomplished using a hyperpolarized choline analog and (13)C-NMR. This represents the first observation of an aldehyde intermediate on hyperpolarized MR and opens the way for kinetic studies of oxidase/dehydrogenase enzymes in vitro and in vivo.

摘要

使用高极化胆碱类似物和 (13)C-NMR 实现了甜菜醛代谢的高时间分辨率实时监测。这代表了在高极化磁共振中首次观察到醛中间产物，并为体外和体内氧化酶/脱氢酶的动力学研究开辟了道路。