Sher Khalid, Shah Shahnaz, Kumar Suneel
Department of Neurology, Jinnah Postgraduate Medical Centre, Karachi.
J Coll Physicians Surg Pak. 2013 Jul;23(7):472-5.
To determine the etiologic patterns of ischaemic stroke in young adults.
A descriptive study.
Department of Neurology, Jinnah Postgraduate Medical Centre, Karachi, from January to December 2010.
All ischaemic stroke patients aged 15 - 45 years were included. The etiologic patterns were classified using TOAST (Trial of ORG 10172 in acute ischaemic stroke) classification and comparisons were made between different stroke subtypes with reference to traditional risk factors like age, smoking, hypertension, diabetes mellitus and dyslipidemia. Results were described in percentages.
There were 75 cases and higher proportion of patients had ischaemic stroke due to cardiac etiology below the age of 35 years. Nineteen patients had cardioembolic stroke [8 (42.1%) males and 11 (57.9%) females]; 15 patients had large artery atherosclerosis [males 9 (60%), females 6 (40%)]; 17 patients had stroke of determined etiology (SDE), [6 (35.2%) males and 11 (64.8%) females] among whom 47% were due to venous sinus thrombosis. Twelve patients had stroke of undetermined etiology (SUE), [5 (41.6%) males and 7 (58.4%) females] and 12 patients had stroke due to small vessel disease (SVD) [8 males (66.7%) and 4 (33.3%) females.
Cardioembolism, venous sinus thrombosis and premature atherosclerosis are common etiologies in young patients with acute ischaemic stroke.
确定青年缺血性脑卒中的病因模式。
描述性研究。
2010年1月至12月，卡拉奇真纳研究生医学中心神经内科。
纳入所有年龄在15 - 45岁的缺血性脑卒中患者。采用TOAST（急性缺血性脑卒中ORG 10172试验）分类法对病因模式进行分类，并参照年龄、吸烟、高血压、糖尿病和血脂异常等传统危险因素，对不同卒中亚型进行比较。结果以百分比表示。
共75例患者，35岁以下因心脏病因导致缺血性脑卒中的患者比例较高。19例为心源性脑栓塞性卒中[男性8例（42.1%），女性11例（57.9%）]；15例为大动脉粥样硬化性卒中[男性9例（60%），女性6例（40%）]；17例为病因明确的卒中（SDE），[男性6例（35.2%），女性11例（64.8%）]，其中47%是由于静脉窦血栓形成。12例为病因不明的卒中（SUE），[男性5例（41.6%），女性7例（58.4%）]，12例为小血管疾病所致卒中（SVD）[男性8例（66.7%），女性4例（33.3%）]。
心源性栓塞、静脉窦血栓形成和过早动脉粥样硬化是青年急性缺血性脑卒中患者的常见病因。
