Inositol Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Building 101/Room No. F-247, Research Triangle Park, NC, 27709, USA,
Amino Acids. 2013 Oct;45(4):751-4. doi: 10.1007/s00726-013-1512-2. Epub 2013 Jul 4.
Proteins with polybasic clusters bind to negatively charged phosphoinositides at the cell membrane. In this review, I have briefly discussed the types of phosphoinositides naturally found on membrane surfaces and how they recruit protein complexes for carrying out the process of signal transduction. A large number of researchers from around the world are now focusing their attention on protein-membrane binding, as these interactions have started to offer us a much better insight into the process of cell signaling. The main areas discussed in this brief review article include the phosphoinositide binding specificities of proteins and the role of their lipid binding in signaling processes downstream of membrane recruitment.
具有多碱性簇的蛋白质与细胞膜上带负电荷的磷酯酰肌醇结合。在这篇综述中，我简要讨论了天然存在于膜表面的磷酯酰肌醇的类型，以及它们如何招募蛋白复合物来进行信号转导过程。现在，来自世界各地的大量研究人员开始关注蛋白质-膜结合，因为这些相互作用开始为我们提供更深入的了解细胞信号转导过程。本文简要综述了蛋白质与磷酯酰肌醇的结合特异性，以及它们的脂质结合在膜招募下游信号过程中的作用。
