Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan.
Adv Exp Med Biol. 2019;1111:139-157. doi: 10.1007/5584_2018_295.
The integrity of cellular membranes is maintained not only by structural phospholipids such as phosphatidylcholine and phosphatidylethanolamine, but also by regulatory phospholipids, phosphatidylinositol phosphates (phosphoinositides). Although phosphoinositides constitute minor membrane phospholipids, they exert a wide variety of regulatory functions in all eukaryotic cells. They act as key markers of membrane surfaces that determine the biological integrity of cellular compartments to recruit various phosphoinositide-binding proteins. This review focuses on recent progress on the significance of phosphoinositides, their modifying enzymes, and phosphoinositide-binding proteins in Arabidopsis.
细胞膜的完整性不仅由结构磷脂如磷脂酰胆碱和磷脂酰乙醇胺维持，还由调节性磷脂，即磷脂酰肌醇磷酸（磷酯酰肌醇）维持。尽管磷酯酰肌醇构成了膜磷脂的一小部分，但它们在所有真核细胞中发挥着广泛的调节功能。它们作为决定细胞区室生物完整性的膜表面的关键标记物，招募各种磷酯酰肌醇结合蛋白。这篇综述重点介绍了近年来在拟南芥中磷酯酰肌醇、其修饰酶和磷酯酰肌醇结合蛋白的重要意义方面的进展。
