Iannilli Francesca, Zalfa Francesca, Gartner Annette, Bagni Claudia, Dotti Carlos G
Center for Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium.
PLoS One. 2013 Jun 18;8(6):e66602. doi: 10.1371/journal.pone.0066602. Print 2013.
The main role of Telomerase Reverse Transcriptase (TERT) is to protect telomere length from shortening during cell division. However, recent works have revealed the existence of a pool of TERT associated to mitochondria, where it plays a role in survival. We here show that in fully differentiated neurons the largest pool of cytoplasmic TERT associates to TIA1 positive RNA granules, where it binds the messenger RNA of the cyclin kinase inhibitor p15INK4B. Upon stress, p15INK4B and TERT dissociate and p15INK4B undergoes efficient translation, allowing its pro-survival function. These results unveil another mechanism implicated in the survival of fully differentiated neurons.
端粒酶逆转录酶（TERT）的主要作用是在细胞分裂过程中保护端粒长度不缩短。然而，最近的研究表明存在与线粒体相关的TERT池，它在细胞存活中发挥作用。我们在此表明，在完全分化的神经元中，最大的细胞质TERT池与TIA1阳性RNA颗粒相关，在那里它结合细胞周期蛋白激酶抑制剂p15INK4B的信使RNA。在应激时，p15INK4B和TERT解离，p15INK4B进行高效翻译，从而发挥其促存活功能。这些结果揭示了另一种与完全分化神经元存活相关的机制。
