人体支气管β-肾上腺素能受体阻滞的定量评估。
Quantitative assessment of bronchial beta-adrenoceptor blockade in man.
作者信息
Gribbin H R, Baldwin C J, Tattersfield A E
出版信息
Br J Clin Pharmacol. 1979 Jun;7(6):551-6. doi: 10.1111/j.1365-2125.1979.tb04641.x.
Abstract
- We describe a method for assessing bronchial beta-adrenoceptor blockade quantitatively in man. Specific airway conductance is measured after increasing doses of inhaled salbutamol and the extent to which the dose-response curve is displaced to the right after beta-adrenoceptor blocking drugs is used to assess bronchial beta-adrenoceptor blockade. 2. Salbutamol dose-response curves were plotted for six normal subjects by measuring sGaw 15 min after increasing doses of inhaled salbutamol. Salbutamol produced a 30-70% increase in sGaw. 3. Salbutamol dose response curves were obtained 2 h after oral practolol (100 mg and 200 mg) and oral propranolol (40 mg and 80 mg) on separate days and were displaced to the right. 4. The mean dose ratios for practolol 100 mg and 200 mg were 1.2 and 2.1 and for propranolol 40 mg and 80 mg they were 21 and 61 respectively.
摘要
- 我们描述了一种在人体中定量评估支气管β-肾上腺素能受体阻滞的方法。在吸入递增剂量的沙丁胺醇后测量比气道传导率，并利用β-肾上腺素能受体阻断药物使用后剂量-反应曲线向右移位的程度来评估支气管β-肾上腺素能受体阻滞。2. 通过在吸入递增剂量的沙丁胺醇15分钟后测量比气道传导率，为6名正常受试者绘制了沙丁胺醇剂量-反应曲线。沙丁胺醇使比气道传导率增加了30%-70%。3. 在不同日期口服心得宁（100毫克和200毫克）和心得安（40毫克和80毫克）2小时后获得沙丁胺醇剂量-反应曲线，且曲线均向右移位。4. 100毫克和200毫克心得宁的平均剂量比分别为1.2和2.1，40毫克和80毫克心得安的平均剂量比分别为21和61。
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