长链非编码 RNA：基因组学、进化与机制。
lincRNAs: genomics, evolution, and mechanisms.
机构信息
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
出版信息
Cell. 2013 Jul 3;154(1):26-46. doi: 10.1016/j.cell.2013.06.020.
Abstract
Long intervening noncoding RNAs (lincRNAs) are transcribed from thousands of loci in mammalian genomes and might play widespread roles in gene regulation and other cellular processes. This Review outlines the emerging understanding of lincRNAs in vertebrate animals, with emphases on how they are being identified and current conclusions and questions regarding their genomics, evolution and mechanisms of action.
摘要
长链非编码 RNA（lincRNAs）是从哺乳动物基因组中的数千个位点转录而来的，可能在基因调控和其他细胞过程中发挥广泛作用。这篇综述概述了脊椎动物中 lincRNAs 的最新研究进展，重点介绍了它们的鉴定方法以及关于它们的基因组学、进化和作用机制的现有结论和问题。
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