长基因间非编码 RNA 的功能和独特特征。
The functions and unique features of long intergenic non-coding RNA.
机构信息
Program in Epithelial Biology, Stanford University School of Medicine, California 94305, USA.
Veterans Affairs Palo Alto Healthcare System, Palo Alto, California 94304, USA.
出版信息
Nat Rev Mol Cell Biol. 2018 Mar;19(3):143-157. doi: 10.1038/nrm.2017.104. Epub 2017 Nov 15.
Abstract
Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish them from mRNA-encoding genes and exercise functions such as remodelling chromatin and genome architecture, RNA stabilization and transcription regulation, including enhancer-associated activity. Some genes currently annotated as encoding lincRNAs include small open reading frames (smORFs) and encode functional peptides and thus may be more properly classified as coding RNAs. lincRNAs may broadly serve to fine-tune the expression of neighbouring genes with remarkable tissue specificity through a diversity of mechanisms, highlighting our rapidly evolving understanding of the non-coding genome.
摘要
长链非编码 RNA（lincRNA）基因具有多种特征，使其有别于编码 mRNA 的基因，并发挥重塑染色质和基因组结构、RNA 稳定和转录调控等功能，包括增强子相关活性。目前被注释为编码 lincRNA 的一些基因包括小开放阅读框（smORFs），并编码功能性肽，因此可能更恰当地归类为编码 RNA。lincRNA 可能通过多种机制广泛地精细调节邻近基因的表达，具有显著的组织特异性，突出了我们对非编码基因组的快速发展的理解。
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