Clin Chem Lab Med. 2013 Oct;51(10):1919-23. doi: 10.1515/cclm-2013-0431.
The international recommendations of the Kidney Disease: Improving Global Outcomes (KDIGO) to define chronic kidney disease (CKD) and classify patients in CKD stages are discussed in an opinion paper published in this issue of the journal. In this counterpoint, we will review some questions and criticisms raised by the authors to provide further contribution on the issue. In particular, we would like to discuss the age issue in the definition of CKD, the validity of the KDIGO staging, the validity of creatinine-based equations for the estimation of the glomerular filtration rate (GFR), as well as the clinical value of cystatin C and the epidemiological rather than clinical nature of the arguments proposed to justify recommendations in the KDIGO guidelines.
国际肾脏病学会-改善全球肾脏病预后组织（KDIGO）的慢性肾脏病（CKD）定义和分期的国际建议在本期杂志的一篇观点文章中进行了讨论。在这篇反驳文章中，我们将回顾作者提出的一些问题和批评，以就该问题提供进一步的贡献。特别是，我们希望讨论 CKD 定义中的年龄问题、KDIGO 分期的有效性、基于肌酐的肾小球滤过率（GFR）估计方程的有效性，以及胱抑素 C 的临床价值，以及流行病学而非临床性质的论据，以证明 KDIGO 指南建议的合理性。
