犯罪现场的牛乳头瘤病毒：E5 致癌基因是否是唯一的罪魁祸首？
Bovine papillomavirus on the scene of crime: is E5 oncogene the only guilty party?
机构信息
Department of Veterinary medicine and Animal productions, University of Naples Federico II, Via F, Delpino, 1-80137, Naples, Italy.
出版信息
Infect Agent Cancer. 2013 Jul 5;8(1):26. doi: 10.1186/1750-9378-8-26.
Abstract
Bovine papillomaviruses (BPVs) induce hyperplastic and tumoral lesions not only in cows but also in other different animal species. The transforming activity of BPVs is due to its major E5 oncogene. Recent studies have highlighted the role of E5 in cancer development but very little is known about E6 and E7 oncogenes. In this letter we argue for the need of investigating E6 as well as E7 to better understand the role of these two oncogenes during carcinogenesis.
摘要
牛乳头瘤病毒（BPV）不仅能诱导奶牛的增生性和肿瘤性病变，还能诱导其他不同动物物种的病变。BPV 的转化活性归因于其主要的 E5 致癌基因。最近的研究强调了 E5 在癌症发展中的作用，但对 E6 和 E7 致癌基因知之甚少。在这封信中，我们认为有必要研究 E6 和 E7，以更好地了解这两个致癌基因在癌变过程中的作用。
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