Laboratório de Fisiologia de Peixes-(LAFIPE), Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria, Santa Maria, RS BR-97105-900, Brazil.
Vet Parasitol. 2013 Nov 8;197(3-4):522-6. doi: 10.1016/j.vetpar.2013.06.012. Epub 2013 Jun 19.
The antiparasitic and antibacterial activities of nitazoxanide (NTZ) against Ichthyophthirius multifiliis (Ich) and Aeromonas hydrophila, respectively, were evaluated in silver catfish juveniles (Rhamdia quelen). In the first experiment, fish naturally infected by Ich were treated with different concentrations of NTZ. Fish mortality and the number of trophonts/juveniles were evaluated. In the second experiment, the antimicrobial potential in vitro (MIC test) and preventive potential in vivo against A. hydrophila was evaluated. The treatment with 1.5mgL(-1) NTZ showed the best result against Ich, with a significant reduction of trophonts and fish mortality of 10%. NTZ did not show in vitro activity against A. hydrophila at concentrations tested, but showed a probable preventive activity in vivo. However, these results are preliminary and more studies should be conducted.
硝唑尼特（NTZ）对多子小瓜虫（Ich）和嗜水气单胞菌的抗寄生虫和抗菌活性分别在南美拟鲿（Rhamdia quelen）幼鱼中进行了评估。在第一个实验中，用不同浓度的 NTZ 处理自然感染 Ich 的鱼。评估了鱼的死亡率和滋养体/幼鱼的数量。在第二个实验中，评估了体外的抗菌潜力（MIC 试验）和体内对嗜水气单胞菌的预防潜力。1.5mg/L NTZ 的治疗对 Ich 表现出最佳效果，滋养体和鱼死亡率显著降低了 10%。NTZ 在测试浓度下对嗜水气单胞菌没有体外活性，但在体内表现出可能的预防活性。然而，这些结果是初步的，应该进行更多的研究。
