Johnson A M, Teague W G, Flanagan T L, McGahren E D, Kron I L
University of Virginia Health Sciences Center, Charlottesville.
Ann Thorac Surg. 1990 Aug;50(2):277-80. doi: 10.1016/0003-4975(90)90749-v.
The effects of chronic denervation on pulmonary vasculature are not well understood. Three groups of young pigs were prepared: (1) those receiving sham thoracotomy, (2) those having left upper lobectomy alone (innervated left lower lobe), and (3) those receiving left pneumonectomy followed by reimplantation of the left lower lobe (denervated left lower lobe). At 10 weeks after operation, animals were anesthetized and instrumented for study. No changes in baseline pulmonary artery pressure, pulmonary capillary wedge pressure, cardiac output, or pulmonary vascular resistance were observed. With diversion of the entire cardiac output to the left lung or lobe, however, the group with reimplanted lobes had a significantly higher pulmonary artery pressure and pulmonary vascular resistance than the other groups. This may result from chronic denervation of the pulmonary vasculature and receptor upregulation.
慢性去神经支配对肺血管系统的影响尚未完全明确。制备了三组幼猪：（1）接受假开胸手术的猪；（2）仅行左上肺叶切除术的猪（左下肺叶有神经支配）；（3）接受左全肺切除术后再植入左下肺叶的猪（左下肺叶去神经支配）。术后10周，将动物麻醉并安装仪器进行研究。未观察到基线肺动脉压、肺毛细血管楔压、心输出量或肺血管阻力有变化。然而，当全部心输出量转向左肺或左肺叶时，再植入肺叶组的肺动脉压和肺血管阻力显著高于其他组。这可能是由于肺血管系统的慢性去神经支配和受体上调所致。
