SIR Institute for Pharmacy Practice and Policy, Theda Mansholstraat 5b, Leiden 2331JE, Netherlands.
Age Ageing. 2013 Sep;42(5):620-6. doi: 10.1093/ageing/aft083. Epub 2013 Jul 5.
we compared the self-reported medication adherence and knowledge of older patients receiving their drugs via multidose drug dispensing (MDD users) with patients receiving manually dispensed drugs (non-MDD users).
MDD users (≥ 65 years, ≥ 5 oral chronic drugs) were randomly selected from eight Dutch community pharmacies. Non-MDD users (≥ 5 oral chronic drugs) were matched on age and gender. Medication adherence was assessed by using the Medication Adherence Reporting Scale (MARS) and medication knowledge by asking the indication of drugs. Cognitive function was measured with Mini-Mental State Examination (MMSE) for a sub selection of patients.
the percentage of patients being adherent to all drugs was higher for MDD users (n = 119, 81%) compared with non-MDD users (n = 96, 58%, P < 0.001).The percentage of patients with adequate knowledge was lower for MDD users (40%) compared with non-MDD users (79%, P < 0.001). The differences in adherence were independent of knowledge and MMSE scores.
this study shows that older patients receiving their drugs via MDD reported a higher medication adherence compared with patients receiving manually dispensed drugs, despite a lower knowledge and lower cognitive function among patients receiving MDD.
我们比较了通过多剂量药物配给（MDD 用户）接受药物的老年患者和接受手动配药的患者（非 MDD 用户）的自我报告用药依从性和用药知识。
从 8 家荷兰社区药店中随机选择 MDD 用户（≥ 65 岁，≥ 5 种口服慢性病药物）。非 MDD 用户（≥ 5 种口服慢性病药物）按年龄和性别匹配。用药依从性采用用药依从性报告量表（MARS）评估，用药知识通过询问药物的适应症来评估。对部分患者进行了认知功能的简易精神状态检查（MMSE）测试。
与非 MDD 用户（n = 96，58%）相比，MDD 用户（n = 119，81%）对所有药物的依从性更高（P < 0.001）。MDD 用户（40%）的用药知识适当比例低于非 MDD 用户（79%）（P < 0.001）。在知识和 MMSE 评分方面，MDD 用户的用药依从性差异是独立的。
这项研究表明，与接受手动配药的患者相比，通过 MDD 接受药物的老年患者报告的用药依从性更高，尽管 MDD 患者的用药知识和认知功能较低。
