Department of Molecular Microbiology and Microbial Pathogenesis; Center for Women's Infectious Disease Research, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8230, Saint Louis, MO, 63110, USA.
Curr Urol Rep. 2013 Oct;14(5):448-56. doi: 10.1007/s11934-013-0354-5.
Urinary tract infections (UTIs) are common, and over half of women report having had at least one in their lifetime. Nearly a third of these women experience recurrent UTI episodes, but the mechanisms of these recurrences are not fully elucidated. Frequent use of antimicrobials for treatment and prevention of UTIs and other infections has contributed to the evolution of multidrug-resistant microorganisms globally. This is a looming worldwide crisis that has created an urgent need for novel strategies for the treatment and prevention of UTIs. Furthering our understanding of the mechanisms of recurrent UTIs, from both host and bacterial perspectives, will be paramount in developing targeted management strategies. In this review, we discuss recent findings regarding recurrent UTIs in women, including progress in our understanding of the mechanisms of recurrence as well as emerging treatments.
尿路感染（UTIs）很常见，超过一半的女性报告一生中至少患过一次。这些女性中有近三分之一经历过复发性尿路感染发作，但这些复发的机制尚未完全阐明。频繁使用抗生素治疗和预防尿路感染和其他感染导致了全球多药耐药微生物的进化。这是一场迫在眉睫的全球危机，迫切需要新的策略来治疗和预防尿路感染。从宿主和细菌两个方面进一步了解复发性尿路感染的机制对于制定有针对性的管理策略至关重要。在这篇综述中，我们讨论了女性复发性尿路感染的最新发现，包括我们对复发机制的理解以及新出现的治疗方法的进展。
