Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands; Eindhoven Cancer Registry, Comprehensive Cancer Centre South (IKZ), Eindhoven, The Netherlands.
Int J Cancer. 2014 Feb 1;134(3):622-8. doi: 10.1002/ijc.28373. Epub 2013 Aug 5.
Peritoneal carcinomatosis (PC) is an important cause of morbidity and mortality among patients with gastric cancer. The aim of the current study was to provide reliable population-based data on the incidence, risk factors and prognosis of PC of gastric origin. All patients diagnosed with gastric cancer in the area of the Eindhoven Cancer Registry between 1995 and 2011 were included. Incidence and survival were computed and risk factors for peritoneal carcinomatosis were determined using multivariate logistic regression analysis. In total, 5,220 patients were diagnosed with gastric cancer, of whom 2,029 (39%) presented with metastatic disease. PC was present in 706 patients (14%) of whom 491 patients (9%) had PC as the only metastatic site. Younger age (<60 years), female gender, advanced T- and N-stage, primary tumor of signet ring cells or linitis plastica and primary tumors covering multiple anatomical locations of the stomach were all associated with a higher odds ratios of developing PC. Median survival of patients without metastases was 14 months, but only 4 months for patients with PC. PC is a frequent condition in patients presenting with gastric cancer, especially in younger patients with advanced tumor stages. Given the detrimental influence of PC on survival, efforts should be undertaken to further explore the promising results that were obtained in preventing or treating this condition with multimodality strategies.
腹膜癌转移（PC）是胃癌患者发病率和死亡率的重要原因。本研究旨在提供可靠的基于人群的胃来源 PC 的发病率、危险因素和预后数据。所有在 1995 年至 2011 年间被 Eindhoven 癌症登记处诊断为胃癌的患者均被纳入研究。计算发病率和生存率，并使用多变量逻辑回归分析确定腹膜癌转移的危险因素。共诊断出 5220 例胃癌患者，其中 2029 例（39%）为转移性疾病。706 例患者存在腹膜癌转移，其中 491 例（9%）为唯一的转移部位。年龄较轻（<60 岁）、女性、较晚期的 T 和 N 分期、原发肿瘤为印戒细胞癌或皮革胃以及原发肿瘤覆盖胃的多个解剖部位均与更高的发生 PC 的比值比相关。无转移患者的中位生存时间为 14 个月，但 PC 患者仅为 4 个月。PC 是胃癌患者中常见的情况，尤其是在较年轻、肿瘤分期较晚的患者中。鉴于 PC 对生存的不利影响，应努力进一步探索在预防或治疗这种疾病方面采用多模式策略所获得的有希望的结果。
