Division of Surgical Oncology, Loma Linda University Health, Loma Linda, California, USA.
School of Public Health, Loma Linda University, Loma Linda, California, USA.
J Surg Oncol. 2020 Dec;122(8):1624-1629. doi: 10.1002/jso.26210. Epub 2020 Sep 9.
A recent study from our group identified Hispanic race/ethnicity as an independent predictor of peritoneal carcinomatosis (PC) in gastric cancer. We sought to identify the tumor factors that might contribute to this strong association in Hispanics.
California Cancer Registry data were used to identify patients diagnosed with gastric adenocarcinoma from 2004 to 2014. Logistic regression analyses were performed to determine odds ratios for cancer stage, tumor location, grade, histology, and PC.
Of 16,275 patients with gastric adenocarcinoma who met inclusion criteria, 6463 (39.7%) were non-Hispanic White (NHW), 4953 (30.4%) were Hispanic, 1020 (6.3%) were non-Hispanic Black (NHB), and 3915 (23.6%) were Asian/other. Compared to NHW, Hispanics were more likely to have a poorly differentiated grade (65.9% vs. 57.6%; p < .001), signet ring adenocarcinoma (28.1% vs. 17.6%; p < .001) and stage IV (51.9% vs. 45.0%; p < .001) gastric cancer. The proportion of stage IV patients with PC was also significantly higher in Hispanics compared to NHW, NHB, and Asian/other (28.5% vs. 16.6%, 20.5%, and 25.2%, respectively; p < .001).
Hispanic ethnicity is an independent predictor of aggressive tumor phenotype and PC. Disproportionate incidence of signet ring adenocarcinoma and PC highlight the need to explore the genomic differences in Hispanic gastric cancer.
本团队最近的一项研究发现，西班牙裔种族是胃癌腹膜转移（PC）的独立预测因素。我们试图确定可能导致西班牙裔人群中这种强关联的肿瘤因素。
使用加利福尼亚癌症登记处的数据，从 2004 年至 2014 年，确定诊断为胃腺癌的患者。采用 logistic 回归分析，确定癌症分期、肿瘤位置、分级、组织学和 PC 的比值比。
在符合纳入标准的 16275 例胃腺癌患者中，6463 例（39.7%）为非西班牙裔白人（NHW），4953 例（30.4%）为西班牙裔，1020 例（6.3%）为非西班牙裔黑人（NHB），3915 例（23.6%）为亚洲/其他。与 NHW 相比，西班牙裔患者更有可能出现低分化分级（65.9% vs. 57.6%；p<0.001）、印戒细胞腺癌（28.1% vs. 17.6%；p<0.001）和 IV 期（51.9% vs. 45.0%；p<0.001）胃癌。与 NHW、NHB 和亚洲/其他相比，IV 期伴有 PC 的患者比例在西班牙裔中也显著更高（28.5% vs. 16.6%、20.5%和 25.2%；p<0.001）。
西班牙裔种族是侵袭性肿瘤表型和 PC 的独立预测因素。印戒细胞腺癌和 PC 的发病率不成比例，突出了需要探索西班牙裔胃癌的基因组差异。
