Ogata Jun, Yamanishi Hiromichi, Ishibashi-Ueda Hatsue
Hirakata General Hospital for Developmental Disorders, Japan.
Brain Nerve. 2013 Jul;65(7):879-85.
This review describes the principal vessel histopathology in sporadic cerebral amyloid angiopathy (CAA). In sporadic CAA, β-amyloid is deposited on the lobar intracortical and leptomeningeal vessel wall. Fibrinoid necrosis, fibrohyalinous intimal thickening, microaneurysms, luminal stenosis, and inflammatory cell infiltration of the involved vessels appear subsequent to the amyloid deposition. The histopathology of sporadic CAA is described in comparison with that of hypertensive vasculopathy, both of which are the most common forms of cerebral small vessel disease.
本综述描述了散发性脑淀粉样血管病（CAA）的主要血管组织病理学特征。在散发性CAA中，β淀粉样蛋白沉积于脑叶皮质内和软脑膜血管壁。在淀粉样蛋白沉积之后，受累血管会出现纤维素样坏死、纤维透明样内膜增厚、微动脉瘤、管腔狭窄和炎症细胞浸润。本文将散发性CAA的组织病理学与高血压性血管病的组织病理学进行了比较，这两种疾病都是脑小血管病最常见的形式。
