Pellerano C, Savini L, Massarelli P, Bruni G, Fiaschi A I
Dipartimento Farmaco Chimico Tecnologico dell'Università, Siena.
Farmaco. 1990 Mar;45(3):269-84.
New 4-anilinoquinoline-3-carboxylic acids, N-[3-carboxyquinolyl (4)]anthranilic acids and their corresponding esters were synthetized by reacting 4-chloro-3-carbethoxyquinolines with substituted anilines and methyl anthranilate respectively. All the compounds were tested for antiinflammatory and analgesic activities. Some derivatives showed a significant antiinflammatory activity comparable to that of indomethacin.
通过分别使4-氯-3-乙氧羰基喹啉与取代苯胺和邻氨基苯甲酸甲酯反应，合成了新型4-苯胺基喹啉-3-羧酸、N-[3-羧基喹啉基(4)]邻氨基苯甲酸及其相应的酯。对所有化合物进行了抗炎和镇痛活性测试。一些衍生物显示出与吲哚美辛相当的显著抗炎活性。
