Synthesis and antiinflammatory activity of some N-(5-substituted indole-3-ylglyoxyl)amine derivatives.
作者信息
Da Settimo A, Primofiore G, Marini A M, Mori C, Franzone J S, Cirillo R, Reboani C
机构信息
Istituto di Chimica Farmaceutica, Università di Pisa, Italy.
出版信息
Farmaco Sci. 1987 Jan;42(1):17-26.
PMID:3502565
Abstract
The synthesis of some amidic derivatives, obtained by condensation of various 5-substituted indoleglyoxylchlorides with physiologically important amines as tyramine, tryptamine and 5-aminouracil, is described. The preparation of one glycolyl derivative is also reported. Study of analgesic and antiinflammatory properties has shown only a feeble activity of these compounds.
摘要
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