Daidone G, Raffa D, Maggio B, Plescia S, Matera M, Caruso A
Dipartimento di Chimica e Tecnologie Farmaceutiche, Università di Parlermo.
Farmaco. 1990 Mar;45(3):285-92.
The analgesic and antiinflammatory activities of some N,N'-bis(2-hydroxybenzoyl)-diaminoalkanes 3 a-l were studied. The compounds were prepared very conveniently by fusion of phenyl salicylate 2 and diaminoalkanes 1 a-l. The pharmacological activities were influenced by the number of carbon atoms in the polimethylenic chain. Some derivatives were more effective and less gastrolesive than salicylamide.
研究了一些N，N'-双（2-羟基苯甲酰基）-二氨基烷烃3 a-l的镇痛和抗炎活性。通过水杨酸苯酯2与二氨基烷烃1 a-l熔融可非常方便地制备这些化合物。药理活性受聚亚甲基链中碳原子数的影响。一些衍生物比水杨酰胺更有效且对胃的刺激性更小。
