Yang Wan-Zhang, Shu Guo-Jian, Zhang Yun, Wu Fang, Ye Bi-Yu, Hu Xiang
Shenzhen Beike Cell Engineering Research Institute, 2/F, Yuanxing Technology Building, #1 Songpingshan Street, North Area, Hi-Tech Industrial Park, Shenzhen 518057, China.
J Med Case Rep. 2013 Jul 8;7:181. doi: 10.1186/1752-1947-7-181.
Herpes simplex virus is the most common cause of sporadic viral encephalitis. Cognitive impairments persist in most patients who survive herpes simplex virus-caused encephalitis after undergoing currently available treatments. This is the first report on the development of human cord blood-derived mononuclear cell transplantation as a new treatment intervention to improve the prognosis of sequelae of viral encephalitis.
An 11-year-old Han Chinese boy developed sequelae of viral encephalitis with cognitive, mental and motor impairments in the 8 months following routine treatments. Since receiving allogeneic cord blood-derived mononuclear cell transplantation combined with comprehensive rehabilitation therapies 7 years ago, the patient's health has significantly improved and remained stable.
Human cord blood-derived mononuclear cell transplantation may be a potential therapeutic strategy for treating the neuropsychiatric and neurobehavioral sequelae of viral encephalitis.
单纯疱疹病毒是散发性病毒性脑炎最常见的病因。在接受现有治疗后，大多数存活的单纯疱疹病毒性脑炎患者仍存在认知障碍。这是关于将人脐带血来源的单核细胞移植作为一种新的治疗干预措施以改善病毒性脑炎后遗症预后的首次报告。
一名11岁的汉族男孩在常规治疗后的8个月出现了病毒性脑炎后遗症，伴有认知、精神和运动障碍。自7年前接受异基因脐带血来源的单核细胞移植并结合综合康复治疗以来，患者的健康状况有了显著改善并保持稳定。
人脐带血来源的单核细胞移植可能是治疗病毒性脑炎神经精神和神经行为后遗症的一种潜在治疗策略。
