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日本使用 iPS 细胞治疗人类临床试验的展望：迈向干细胞治疗的前沿。

Perspectives on human clinical trials of therapies using iPS cells in Japan: reaching the forefront of stem-cell therapies.

机构信息

Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

出版信息

Biosci Trends. 2013 Jun;7(3):157-8.

PMID:23836040
Abstract

A research project involving sheets of retinal pigment epithelium constructed from iPS cells derived from patients with age-related maculopathy is one step closer to being approved for clinical trials by the Japanese Government. Now is the time to make therapies using iPS cells clinically available.

摘要

一个涉及由源自年龄相关性黄斑病变患者的诱导多能干细胞构建的视网膜色素上皮细胞片的研究项目，距离日本政府批准临床试验又近了一步。现在是将使用 iPS 细胞的疗法推向临床应用的时候了。

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1
Perspectives on human clinical trials of therapies using iPS cells in Japan: reaching the forefront of stem-cell therapies.日本使用 iPS 细胞治疗人类临床试验的展望：迈向干细胞治疗的前沿。
Biosci Trends. 2013 Jun;7(3):157-8.
2
[Development of novel therapies using human iPS cell-derived retinal pigment epithelia].[利用人诱导多能干细胞衍生的视网膜色素上皮开发新型疗法]
Nihon Yakurigaku Zasshi. 2016;148(4):217. doi: 10.1254/fpj.148.217.
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[Retinal regeneration with iPS cells ‒ Clinical trials for retinal degenerative disorders].[诱导多能干细胞用于视网膜再生——视网膜退行性疾病的临床试验]
Nihon Rinsho Meneki Gakkai Kaishi. 2015;38(2):79-85. doi: 10.2177/jsci.38.79.
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Fabricating retinal pigment epithelial cell sheets derived from human induced pluripotent stem cells in an automated closed culture system for regenerative medicine.在自动化封闭培养系统中制造源自人诱导多能干细胞的视网膜色素上皮细胞片用于再生医学。
PLoS One. 2019 Mar 13;14(3):e0212369. doi: 10.1371/journal.pone.0212369. eCollection 2019.
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What's old is new again: Autologous stem cell transplant for AMD.旧闻新提：AMD 的自体干细胞移植。
Sci Transl Med. 2017 Apr 26;9(387). doi: 10.1126/scitranslmed.aan2783.
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Differentiation of human pluripotent stem cells to retinal pigmented epithelium in defined conditions using purified extracellular matrix proteins.在确定的条件下使用纯化的细胞外基质蛋白将人多能干细胞分化为视网膜色素上皮细胞。
J Tissue Eng Regen Med. 2013 Aug;7(8):642-53. doi: 10.1002/term.1458. Epub 2012 Apr 18.
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Stem Cell Treatment for Age-Related Macular Degeneration: the Challenges.用于年龄相关性黄斑变性的干细胞治疗：挑战
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Concise Review: Making Stem Cells Retinal: Methods for Deriving Retinal Pigment Epithelium and Implications for Patients With Ocular Disease.简明综述：诱导干细胞成为视网膜细胞——用于诱导视网膜色素上皮细胞的方法及其对眼部疾病患者的意义。
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Cell-Based Therapy for Degenerative Retinal Disease.基于细胞的退行性视网膜疾病治疗。
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Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration.自体诱导干细胞衍生的视网膜细胞治疗黄斑变性。
N Engl J Med. 2017 Mar 16;376(11):1038-1046. doi: 10.1056/NEJMoa1608368.

引用本文的文献

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In situ regeneration of retinal pigment epithelium by gene transfer of E2F2: a potential strategy for treatment of macular degenerations.通过 E2F2 基因转移实现视网膜色素上皮的原位再生：治疗黄斑变性的潜在策略。
Gene Ther. 2017 Dec;24(12):810-818. doi: 10.1038/gt.2017.89. Epub 2017 Nov 30.
2
Role of the Hedgehog Signaling Pathway in Regulating the Behavior of Germline Stem Cells.刺猬信号通路在调节生殖系干细胞行为中的作用。
Stem Cells Int. 2017;2017:5714608. doi: 10.1155/2017/5714608. Epub 2017 Aug 13.
3
Human induced pluripotent stem cells for monogenic disease modelling and therapy.
用于单基因疾病建模与治疗的人类诱导多能干细胞。
World J Stem Cells. 2016 Apr 26;8(4):118-35. doi: 10.4252/wjsc.v8.i4.118.
4
Generation of clinical-grade human induced pluripotent stem cells in Xeno-free conditions.在无血清条件下生成临床级人诱导多能干细胞。
Stem Cell Res Ther. 2015 Nov 12;6:223. doi: 10.1186/s13287-015-0206-y.
5
Stem Cell Differentiation and Therapeutic Use.
Stem Cells Int. 2015;2015:308128. doi: 10.1155/2015/308128. Epub 2015 Aug 4.
6
Biobanking of Human Retinas: The Next Big Leap for Eye Banks?人类视网膜生物样本库：眼库的下一个重大飞跃？
Stem Cells Transl Med. 2015 Aug;4(8):868-72. doi: 10.5966/sctm.2015-0061. Epub 2015 Jun 1.
7
Activated adult microglia influence retinal progenitor cell proliferation and differentiation toward recoverin-expressing neuron-like cells in a co-culture model.在共培养模型中，活化的成年小胶质细胞影响视网膜祖细胞的增殖以及向表达恢复蛋白的神经元样细胞的分化。
Graefes Arch Clin Exp Ophthalmol. 2015 Jul;253(7):1085-96. doi: 10.1007/s00417-015-2961-y. Epub 2015 Feb 14.
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The potential of stem cell-based therapy for retinal repair.基于干细胞的视网膜修复疗法的潜力。
Neural Regen Res. 2014 Jun 1;9(11):1100-3. doi: 10.4103/1673-5374.135311.
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Enhancing RPE Cell-Based Therapy Outcomes for AMD: The Role of Bruch's Membrane.增强基于视网膜色素上皮细胞的年龄相关性黄斑变性治疗效果：布鲁赫膜的作用。
Transl Vis Sci Technol. 2014 Jul 3;3(3):11. doi: 10.1167/tvst.3.3.11. eCollection 2014 Jun.