Division of Plastic and Reconstructive Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
Microsurgery. 2013 Sep;33(6):432-8. doi: 10.1002/micr.22107. Epub 2013 Jul 9.
Thrombosis is a common cause of flap failure in microvascular tissue transfer, which questions the effects of anemia on this outcome. This article seeks to contribute a large, multi-institutional data analysis to this debate.
Free tissue transfer patients were identified in the National Surgical Quality Improvement database through a specified Current Procedural Terminology algorithm. Bivariate analysis compared anemic and nonanemic groups with respect to flap failure and other outcomes. Multivariable logistic regression was used to determine risk factors for flap failure.
Of the 864 patients who met inclusion criteria, 244 were anemic and 620 were not. Bivariate analysis showed no significant difference between groups with respect to flap failure (3.28% vs. 4.03%, P = 0.0603). Multivariate regression analysis supported this (OR 95% CI = 0.371-1.912).
These findings, based on the largest sample in the literature, show anemia is neither a predictor of free tissue transfer failure nor is it protective.
血栓是导致微血管组织移植皮瓣失败的常见原因，这使得人们质疑贫血对此结果的影响。本文旨在为这一争议提供大量多机构数据分析。
通过特定的当前程序术语算法，在国家手术质量改进数据库中确定游离组织转移患者。使用双变量分析比较贫血组和非贫血组的皮瓣失败和其他结局。使用多变量逻辑回归确定皮瓣失败的危险因素。
在符合纳入标准的 864 名患者中，244 名患者贫血，620 名患者不贫血。双变量分析显示两组在皮瓣失败方面无显著差异（3.28%比 4.03%，P = 0.0603）。多变量回归分析支持这一点（OR 95%CI=0.371-1.912）。
这些基于文献中最大样本的发现表明，贫血既不是游离组织转移失败的预测因素，也不是保护因素。
