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自体活性组织生物管的组织学和力学特性

Histological and mechanical properties of autologous living tissue biotubes.

作者信息

Chen Xiao-Song, Ou Tong-Wen, Zhang Jian, Li Jian-Xin, Chen Bing, Yu Heng-Xi, Gu Yong-Quan, Cui Ye-Qing, Zhang Jing-Yan, Xu Yan-Ling, Sun Han-Chen, Liu Shuang, Wang Rong

机构信息

Departments of Urology, Xuanwu Hospital, Capital Medical University, Beijing 100053, P.R. China.

出版信息

Exp Ther Med. 2013 Jun;5(6):1613-1618. doi: 10.3892/etm.2013.1040. Epub 2013 Apr 2.

DOI:10.3892/etm.2013.1040
PMID:23837041
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3702706/
Abstract

The aim of this study was to explore and evaluate biotubes consisting of autologous tissues. The biotubes were prepared by intra-abdominally embedding silicon rods as moulds. The specimens were analyzed by mechanical tests, histological observation and superficial study. The intra-abdominal implantation of the silicone tubes readily stimulated the development of the biotubes. The biotubes consisted of collagen-rich extracellular matrices. Myofibroblasts appeared as elongated cells with circumferential or longitudinal orientations. Subsequent to one month of embedding, the thickness of the tube wall was 70-250 m. The burst strength was 1100±187 mmHg and the suturability was excellent. Biotubes that have the ability to be widely variable in their shapes are composed of autologous cells and glomerular extracellular matrices. Biotubes are ideal grafts for tissue engineering as they are able to avoid immunological rejection and are of sufficient mechanical strength.

摘要

本研究的目的是探索和评估由自体组织构成的生物管。生物管通过将硅棒作为模具腹腔内植入制备而成。通过力学测试、组织学观察和表面研究对标本进行分析。硅胶管腹腔内植入容易刺激生物管的发育。生物管由富含胶原蛋白的细胞外基质组成。肌成纤维细胞表现为具有圆周或纵向取向的细长细胞。植入一个月后，管壁厚度为70 - 250微米。破裂强度为1100±187毫米汞柱，缝合性极佳。能够在形状上广泛变化的生物管由自体细胞和肾小球细胞外基质组成。生物管是组织工程的理想移植物，因为它们能够避免免疫排斥且具有足够的机械强度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1244/3702706/cfd39af1b6fe/ETM-05-06-1613-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1244/3702706/5fc7fb8f539b/ETM-05-06-1613-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1244/3702706/e07d11d2042e/ETM-05-06-1613-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1244/3702706/c1ec89373060/ETM-05-06-1613-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1244/3702706/e4e9779a67f8/ETM-05-06-1613-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1244/3702706/cd2cee0ad43c/ETM-05-06-1613-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1244/3702706/cfd39af1b6fe/ETM-05-06-1613-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1244/3702706/5fc7fb8f539b/ETM-05-06-1613-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1244/3702706/e07d11d2042e/ETM-05-06-1613-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1244/3702706/c1ec89373060/ETM-05-06-1613-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1244/3702706/e4e9779a67f8/ETM-05-06-1613-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1244/3702706/cd2cee0ad43c/ETM-05-06-1613-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1244/3702706/cfd39af1b6fe/ETM-05-06-1613-g05.jpg

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