Vasili Ermira, Doci Xhiliola, Hysi Katerina
Department of Dermatovenerology, University of Hospital Center Mother Theresa, Tiran Albania.
Cutis. 2013 Jun;91(6):291-4.
Idiopathic calcinosis cutis is an uncommon condition characterized by calcium deposits in the dermis, subcutis, and muscles that most commonly are localized in one area. We report the rare case of a 16-year-old adolescent girl who exhibited unusually widespread calcium deposits. The laboratory results showed a normal biochemistry profile. Ultrasonography revealed calcifications in the fat tissue under the skin but not in deeper tissues or muscles. The histopathologic evaluation showed deep cutaneous and subcutaneous calcium deposits. Laboratory investigation revealed normal calcium, phosphate, and parathyroid hormone levels. Calcium excretion in a 24-hour urine sample was normal, but phosphate excretion was slightly low. Scintigraphic research showed no pathology in the thyroid and parathyroid glands but revealed soft-tissue calcification. A chest roentgenogram, blood tests, and testing of stools for occult blood showed no indication of internal malignancy. On the basis of these findings,the diagnosis of idiopathic calcinosis cutis was made. We discuss the pathogenesis, clinical and histologic picture, and differential diagnosis of calcinosis cutis.
特发性皮肤钙化症是一种罕见病症，其特征为真皮、皮下组织和肌肉中出现钙沉积，且这些沉积大多局限于一个部位。我们报告了一例罕见的16岁青春期女孩病例，其钙沉积异常广泛。实验室检查结果显示生化指标正常。超声检查发现皮肤下脂肪组织中有钙化，但深部组织或肌肉中未发现。组织病理学评估显示皮肤深层和皮下有钙沉积。实验室检查显示钙、磷和甲状旁腺激素水平正常。24小时尿样中的钙排泄正常，但磷排泄略低。闪烁扫描研究显示甲状腺和甲状旁腺无病变，但发现软组织钙化。胸部X线片、血液检查和粪便潜血检查均未显示有内部恶性肿瘤迹象。基于这些发现，做出了特发性皮肤钙化症的诊断。我们讨论了皮肤钙化症的发病机制、临床和组织学表现以及鉴别诊断。
