Zore Zvonimir, Boras Ivanka, Stanec Mladen, Oresić Tomislav, Zore Irina Filipović
Department of Surgical Oncology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.
Acta Clin Croat. 2013 Mar;52(1):35-42.
The aim of this study was to investigate the association of infrared imaging findings and hormone receptor (estrogen and progesterone) status in breast cancers. The study was carried out at Department of Surgical Oncology and Department of Pathology, Sestre milosrdnice University Hospital Center, in collaboration with licensed infrared thermography experts. The study involved 75 female patients with invasive breast tumors. Thermography findings were compared with different immunohistochemical findings (hormone status positive or negative). Seventy-five female patients aged 36 to 86 years, mean age 64 +/- 11.36 years, were examined. The tumor itself and the breast containing the tumor were statistically significantly warmer (p < 0.001) than the healthy breast in all study patients. There was no statistically significant difference (p > 0.05) between patients with positive and those with negative estrogen receptors. Unlike all previously published results of various thermographic studies, results obtained in this study on the hormone receptor status analyzed and its impact on thermographic findings indicated that estrogen negative tumors had a higher maximum and average temperature than estrogen positive tumors. It was also observed that estrogen negative tumors had lower impact on warming of the entire breast, and that maximum and average temperature of the affected breast was higher in estrogen positive tumors. Arithmetic means of maximum and average tumor temperatures were statistically significantly higher for progesterone negative tumors compared with progesterone positive tumors (p < 0.05). Thermographic findings correlated with the specific hormonal status of breast invasive tumors, which reflects the biological behavior of tumors as well as their clinical variables.
本研究的目的是调查红外成像结果与乳腺癌中激素受体（雌激素和孕激素）状态之间的关联。该研究在塞斯特雷·米洛斯拉夫尼察大学医院中心的外科肿瘤学系和病理学系开展，并与持牌红外热成像专家合作进行。该研究纳入了75例患有浸润性乳腺肿瘤的女性患者。将热成像结果与不同的免疫组织化学结果（激素状态阳性或阴性）进行比较。对75例年龄在36至86岁之间、平均年龄为64±11.36岁的女性患者进行了检查。在所有研究患者中，肿瘤本身及包含肿瘤的乳房在统计学上显著比健康乳房更热（p<0.001）。雌激素受体阳性和阴性的患者之间没有统计学上的显著差异（p>0.05）。与之前发表的各种热成像研究结果不同，本研究中关于激素受体状态分析及其对热成像结果影响的研究结果表明，雌激素阴性肿瘤的最高温度和平均温度高于雌激素阳性肿瘤。还观察到，雌激素阴性肿瘤对整个乳房升温的影响较小，而雌激素阳性肿瘤中患侧乳房的最高温度和平均温度较高。与孕激素阳性肿瘤相比，孕激素阴性肿瘤的肿瘤最高温度和平均温度的算术平均值在统计学上显著更高（p<0.05）。热成像结果与乳腺浸润性肿瘤的特定激素状态相关，这反映了肿瘤的生物学行为及其临床变量。
