Tacher Vania, Bhagat Nikhil, Rao Pramod V, Lin Mingde, Schäfer Dirk, Noordhoek Niels, Eshuis Peter, Radaelli Alessandro, Liapi Eleni, Grass Michael, Geschwind Jean-François
Johns Hopkins Hospital, Interventional Radiology , Baltimore, MD , USA.
Minim Invasive Ther Allied Technol. 2013 Sep;22(5):297-303. doi: 10.3109/13645706.2013.788028. Epub 2013 Jul 9.
C-Arm CT (CACT) is a new imaging modality in liver oncology therapy that allows for the acquisition of 3D images intra-procedurally. CACT has been used to enhance intra-arterial therapies for the liver by improving lesion detection, avoiding non-target embolization, and allowing for more selective delivery of agents. However, one of the limitations of this technology is image artifacts created by respiratory motion.
To determine in this preliminary study improvements in image acquisition, motion compensation, and high resolution 3D reconstruction that can improve CACT image quality (IQ).
Three adult male New Zealand white rabbits were used for this study. First, a control rabbit was used to select the best x-ray acquisition imaging protocol and then two rabbits were implanted with liver tumor to further develop 3D image reconstruction and motion compensation algorithms.
The best IQ was obtained using the low 80 kVp protocol with motion compensated reconstruction with high resolution and fast acquisition speed (60 fps, 5 s/scan, and 312 images).
IQ improved by: (1) decreasing acquisition time, (2) applying motion-compensated reconstruction, and (3) high resolution 3D reconstruction. The findings of this study can be applied to future animal studies and eventually could be translated into the clinical environment.
C 型臂 CT（CACT）是肝脏肿瘤治疗中的一种新型成像方式，可在手术过程中获取三维图像。CACT 已被用于通过改善病灶检测、避免非靶栓塞以及实现更具选择性的药物递送，来增强肝脏的动脉内治疗。然而，这项技术的局限性之一是呼吸运动产生的图像伪影。
在这项初步研究中确定图像采集、运动补偿和高分辨率三维重建方面的改进措施，以提高 CACT 图像质量（IQ）。
本研究使用了三只成年雄性新西兰白兔。首先，用一只对照兔选择最佳的 X 射线采集成像方案，然后给两只兔植入肝脏肿瘤，以进一步开发三维图像重建和运动补偿算法。
采用低 80 kVp 方案、具有运动补偿重建、高分辨率和快速采集速度（60 帧/秒、5 秒/扫描和 312 幅图像）时获得了最佳图像质量。
图像质量通过以下方式得到改善：（1）缩短采集时间，（2）应用运动补偿重建，以及（3）进行高分辨率三维重建。本研究结果可应用于未来的动物研究，并最终可转化到临床环境中。
