Zhang Xiangyu, Shen Fang, Dong Lini, Zhao Xiaokun, Qu Xiaobing
Departments of Geriatrics and Urology, Second Xiangya Hospital of Central South University, Changsha, Hunan, P.R. China.
Urol Int. 2013;91(4):467-73. doi: 10.1159/000350519. Epub 2013 Jul 6.
To explore the effects and mechanisms of simvastatin on prostate hyperplasia in spontaneously hypertensive rats (SHRs).
Thirty-six male SHRs were randomly divided into three groups: the 10 and the 20 mg/kg/d simvastatin group and the control group. After 6 weeks the ultra-microscopic prostate structures were observed. The serum levels of interleukin-6 (IL-6), insulin-like growth factor (IGF-1) and angiotensin II (Ang-II) were measured by enzyme-linked immunosorbent assays. The endothelium-derived nitric oxide synthase (eNOS) expression was evaluated with immunohistochemistry.
Compared to the control group, the 20 mg/kg/d simvastatin group presented with lower absolute (p = 0.005) and relative prostate weight (p = 0.009). The basal cells and columnar cells presented with edema, condensed heterochromatin in interstitial fibroblast nuclei, widened nucleus gaps, and decreased mitochondria and endoplasmic reticulum in the 10 mg/kg/d simvastatin group, these changes were more pronounced in the 20 mg/kg/d simvastatin group. The IL-6 levels in the 10 and 20 mg/kg/d simvastatin groups were lower than those of the controls (p = 0.005 and p = 0.008). The IGF-1 levels of the 20 mg/kg/d simvastatin group were reduced compared to the control group (p = 0.016).
Simvastatin can delay and inhibit prostatic hyperplasia and progression in SHR. These actions may be mediated through the suppression of inflammatory and growth factors.
探讨辛伐他汀对自发性高血压大鼠（SHR）前列腺增生的影响及其机制。
将36只雄性SHR随机分为三组：10mg/kg/d和20mg/kg/d辛伐他汀组及对照组。6周后观察前列腺超微结构。采用酶联免疫吸附测定法检测血清白细胞介素-6（IL-6）、胰岛素样生长因子（IGF-1）和血管紧张素II（Ang-II）水平。用免疫组织化学法评估内皮型一氧化氮合酶（eNOS）表达。
与对照组相比，20mg/kg/d辛伐他汀组的绝对前列腺重量（p = 0.005）和相对前列腺重量较低（p = 0.009）。10mg/kg/d辛伐他汀组的基底细胞和柱状细胞出现水肿，间质成纤维细胞核内异染色质浓缩，核间隙增宽，线粒体和内质网减少，这些变化在20mg/kg/d辛伐他汀组中更明显。10mg/kg/d和20mg/kg/d辛伐他汀组的IL-6水平低于对照组（p = 0.005和p = 0.008）。20mg/kg/d辛伐他汀组的IGF-1水平与对照组相比降低（p = 0.016）。
辛伐他汀可延缓和抑制SHR的前列腺增生及进展。这些作用可能通过抑制炎症和生长因子来介导。
