Department of Gastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita, 879-5593, Japan,
Obes Surg. 2013 Dec;23(12):1947-56. doi: 10.1007/s11695-013-1035-7.
Laparoscopic sleeve gastrectomy (SG) is a popular bariatric procedure for treating morbid obesity. This study aimed to investigate the relation between SG and lipid metabolism in an obese diabetic rat model.
Forty-five male Zucker diabetic fatty (ZDF) rats were divided into three groups: sham-operated (SO) control, gastric banding (GB), and SG. Six weeks after surgery, metabolic parameters, including plasma adiponectin level, small bowel transit, mRNA expression of peroxisome proliferator-activated receptor (PPAR)-α and PPARγ in the liver, skeletal muscle and white adipose tissue, and that of adiponectin in white adipose tissue, and triglyceride (TG) contents in the liver and skeletal muscle were measured.
Metabolic parameters in the GB and SG groups were significantly improved compared with those in the SO group. However, plasma total cholesterol (TC) and free fatty acid (FFA) concentrations were significantly lower while the plasma adiponectin level was significantly higher in the SG group than in the GB and SO groups. In addition, small bowel transit time was significantly shorter in the SG group than in the other two groups. Furthermore, in the SG group, mRNA expression of PPARα in the liver and skeletal muscle and that of adiponection and PPARγ in white adipose tissue were significantly higher, while TG in the liver and skeletal muscle were significantly lower, compared with those in the other two groups.
These results suggest that SG improves lipid metabolism compared with GB, although there were no significant differences in the effect on weight loss between the two procedures.
腹腔镜袖状胃切除术（SG）是治疗病态肥胖的一种流行的减肥手术。本研究旨在研究 SG 与肥胖糖尿病大鼠模型中脂质代谢的关系。
45 只雄性 Zucker 糖尿病肥胖（ZDF）大鼠分为三组：假手术（SO）对照组、胃束带（GB）和 SG。手术后 6 周，测量代谢参数，包括血浆脂联素水平、小肠转运、肝脏、骨骼肌和白色脂肪组织中过氧化物酶体增殖物激活受体（PPAR）-α 和 PPARγ 的 mRNA 表达，以及白色脂肪组织中的脂联素和肝脏和骨骼肌中的甘油三酯（TG）含量。
GB 和 SG 组的代谢参数明显优于 SO 组。然而，与 GB 和 SO 组相比，SG 组的血浆总胆固醇（TC）和游离脂肪酸（FFA）浓度明显降低，而血浆脂联素水平明显升高。此外，SG 组的小肠转运时间明显短于其他两组。此外，与其他两组相比，SG 组肝脏和骨骼肌中 PPARα 的 mRNA 表达、白色脂肪组织中脂联素和 PPARγ 的 mRNA 表达以及肝脏和骨骼肌中的 TG 明显升高。
这些结果表明，SG 改善了脂质代谢，尽管两种手术对减肥的效果没有显著差异。
