Herbort C P, Chan C C, Nussenblatt R B
Laboratory of Immunology, National Eye Institute, Bethesda, MD.
Curr Eye Res. 1990;9 Suppl:119-24. doi: 10.3109/02713689008999430.
Endotoxin-induced Uveitis (EIU) was produced in Lewis rats by footpad injection of Salmonella endotoxin. Protein and cells were measured both in the aqueous humor and in the cerebrospinal fluid (CSF) in order to examine if the inflammation was strictly limited to the anterior uvea. EIU was also induced in Fischer and Brown Norway rats and the inflammation was compared among the three strains. Although the function and structure of the choroid plexus is very similar to the ciliary body, no signs of inflammation were seen in the choroid plexus and the CSF. Among the 3 tested strains of rats, EIU was maximal in Lewis rats, less severe in Fischer rats and least pronounced in Brown Norway rats. It is thought that because of its specific microvascular structure, the ciliary body is specially prone to endotoxin induced inflammation. The amount of inflammation however depends on the genetic background of the animal.
通过足垫注射沙门氏菌内毒素在Lewis大鼠中诱发内毒素性葡萄膜炎（EIU）。检测房水和脑脊液（CSF）中的蛋白质和细胞，以检查炎症是否严格局限于前葡萄膜。还在Fischer大鼠和棕色挪威大鼠中诱发EIU，并比较这三个品系中的炎症情况。尽管脉络丛的功能和结构与睫状体非常相似，但在脉络丛和脑脊液中未观察到炎症迹象。在3个受试大鼠品系中，EIU在Lewis大鼠中最为严重，在Fischer大鼠中较轻，在棕色挪威大鼠中最不明显。据认为，由于其特定的微血管结构，睫状体特别容易受到内毒素诱导的炎症影响。然而，炎症的程度取决于动物的遗传背景。
