Karaman-Kraljević K, Stambuk V, Stambuk N, Kastelan A
Clinical Hospital Centre Firule, University of Zagreb, Yugoslavia.
Curr Eye Res. 1990;9 Suppl:13-6. doi: 10.3109/02713689008999413.
We prospectively studied and classified 152 cases of endogenous uveitis treated at the Ophthalmological Clinic in Split, Yugoslavia, according to clinical presentation, several immunologic parameters including HLA subtyping, and the presence of an associated systemic disease. Using our diagnostic criteria we successfully classified 91.4% of patients. Anterior uveitis was the most common form of clinical presentation (94 patients, 61.8%), whereas an intermediate uveitis was present in only 5.3% of patients (8 patients). By HLA typing we found that 115 patients (75.7%), were positive for HLA-B27 (57 patients, 50%), B5 (30 patients, 26%) and B35 (28 patients, 24%) risk antigens. Of these patients 96 (83%) had an associated systemic illness. In the 8.6% of cases (13 cases) in which the etiology of an endogenous uveitis was not determined, none were associated with an HLA-B risk antigen. Our study emphasizes the association of HLA-B risk antigens and concurrent systemic disease in patients with endogenous uveitis.
我们对在南斯拉夫斯普利特眼科诊所接受治疗的152例内因性葡萄膜炎患者进行了前瞻性研究和分类，依据临床表现、包括HLA分型在内的多项免疫学参数以及是否存在相关全身性疾病进行分类。根据我们的诊断标准，成功对91.4%的患者进行了分类。前葡萄膜炎是最常见的临床表现形式（94例患者，61.8%），而中间葡萄膜炎仅占患者的5.3%（8例患者）。通过HLA分型，我们发现115例患者（75.7%）HLA - B27（57例患者，50%）、B5（30例患者，26%）和B35（28例患者，24%）风险抗原呈阳性。这些患者中有96例（83%）患有相关的全身性疾病。在8.6%的病例（13例）中，内因性葡萄膜炎的病因未明确，且无一例与HLA - B风险抗原相关。我们的研究强调了内因性葡萄膜炎患者中HLA - B风险抗原与并发全身性疾病之间的关联。
